The only thing worse than making a mistake is knowing you steamrolled over the objections of wiser people to make it.
On second thought, a mouthful of spiders would totally be worse. Also, anything that involves dying slowly (but not aging - sure, the average person takes eighty years to die but it's not like you're doing it staked to an anthill). Um, let's see. Divorce, getting a paper cut on your eye, rewatching Irreversible, being bullied in front of your kids, losing your home, living under totalitarianism and that time in Grade 4 when Greg Banks saw Empire Strikes Back before I could and told me Darth Vader was Luke's dad. FUCK YOU, GREG! I HOPE YOU URINATED INTO THE AMAZON RIVER AND HAD ONE OF THOSE WEIRD FISH SWIM UP THE URINE STREAM AND LACERATE YOUR URETHRA WITH ITS SPINES.